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Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp. GD6 associated Chinese mangrove Bruguiera gymnorrhiza / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 358-365, 2018.
Artículo en Inglés | WPRIM | ID: wpr-812394
ABSTRACT
One new sorbicillin derivative, 2-deoxy-sohirnone C (1), one new diketopiperazine alkaloid, 5S-hydroxynorvaline-S-Ile (2), and two naturally occurring diketopiperazines, 3S-hydroxylcyclo(S-Pro-S-Phe) (3) and cyclo(S-Phe-S-Gln) (4), together with three known compounds were isolated from the Chinese mangrove endophytic fungus Penicillium sp. GD6. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison with literature data. The absolute configuration of 3-hydroxyl moiety in 3 was determined by Mosher's method, while the absolute stereochemistry of 2 and 4 was established by comparison with the CD spectra of natural and synthesized diketopiperazines. Compound 1 showed moderate antibacterial activity against Methicillin-resistant Staphylococcus aureus with a MIC value of 80 μg·mL.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Penicillium / Farmacología / Resorcinoles / Estructura Molecular / Pruebas de Sensibilidad Microbiana / Química / China / Dicroismo Circular / Resonancia Magnética Nuclear Biomolecular / Rhizophoraceae País/Región como asunto: Asia Idioma: Inglés Revista: Chinese Journal of Natural Medicines (English Ed.) Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Penicillium / Farmacología / Resorcinoles / Estructura Molecular / Pruebas de Sensibilidad Microbiana / Química / China / Dicroismo Circular / Resonancia Magnética Nuclear Biomolecular / Rhizophoraceae País/Región como asunto: Asia Idioma: Inglés Revista: Chinese Journal of Natural Medicines (English Ed.) Año: 2018 Tipo del documento: Artículo