Chemical constituents from Gnaphalium affine and their xanthine oxidase inhibitory activity / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 347-353, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-812396
ABSTRACT
Gnaphalium affine D. Don, a medicinal and edible plant, has been used to treat gout in traditional Chinese medicine and popularly consumed in China for a long time. A detailed phytochemical investigation on the aerial part of G. affine led to the isolation of two new esters of caffeoylquinic acid named (-) ethyl 1, 4-di-O-caffeoylquinate (1) and (-) methyl 1, 4-di-O-caffeoylquinate (2), together with 35 known compounds (3-37). Their structures were elucidated by spectroscopic data and first-order multiplet analysis. All the isolated compounds were tested for their xanthine oxidase inhibitory activity with an in vitro enzyme inhibitory screening assay. Among the tested compounds, 1 (IC 11.94 μmol·L) and 2 (IC 15.04 μmol·L) showed a good inhibitory activity. The current results supported the medical use of the plant.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Ácido Quínico
/
Xantina Oxidasa
/
Flavonoides
/
Medicamentos Herbarios Chinos
/
Extractos Vegetales
/
Adenina
/
Estructura Molecular
/
Química
/
Supresores de la Gota
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2018
Tipo del documento:
Artículo
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