Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 131-138, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-812423
ABSTRACT
Four new triterpene saponins, mandshunosides F-I (1-4), together with five known compounds (5-9), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis products. Bisdesmosidic saponin (3-9) showed modest suppression of NO production with the inhibition ratios in the range of 51.3%- 64.6% at 50 μmol·L, whereas monodesmosidic saponins with a free carboxyl group at C-28 (1 and 2) showed potent inhibitory activities with IC values being 12.7 and 8.3 μmol·L, respectively.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Saponinas
/
Triterpenos
/
Medicamentos Herbarios Chinos
/
Estructura Molecular
/
Química
/
Rizoma
/
Clematis
/
Macrófagos
/
Metabolismo
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2018
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS