Fumigaclavine I, a new alkaloid isolated from endophyte Aspergillus terreus / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 937-941, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-812461
ABSTRACT
The present study was designed to isolate and purify chemical constituents from solid culture of endophyte Aspergillus terreus LQ, using silica gel column chromatography, gel filtration with Sephadex LH-20, and HPLC. Fumigaclavine I (1), a new alkaloid, was obtained, along with seven known compounds, including fumigaclavine C (2), rhizoctonic acid (3), monomethylsulochrin (4), chaetominine (5), spirotryprostatin A (6), asperfumoid (7), and lumichrome (8). The structure of compound 1 was elucidated by various spectroscopic analyses (UV, MS, 1D and 2D NMR). The in vitro cytotoxicity of compound 1 was determined by MTT assay in human hepatocarcinoma cell line SMMC-7721, showing weaker cytotoxicity, compared with cisplatin, a clinically used cancer chemotherapeutic agent.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Aspergillus
/
Oryza
/
Espectroscopía de Resonancia Magnética
/
Estructura Molecular
/
Supervivencia Celular
/
Química
/
Línea Celular Tumoral
/
Alcaloides de Claviceps
/
Endófitos
/
Microbiología
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2015
Tipo del documento:
Artículo
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