Cancer therapy using natural ligands that target estrogen receptor beta / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 801-807, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-812478
ABSTRACT
Estrogen receptor beta (ERβ) is one of the two key receptors (ERα, ERβ) that facilitate biological actions of 17β-estradiol (E2). ERβ is widely expressed in many tissues, and its expression is reduced or lost during progression of many tumors. ERβ facilitates estrogen signaling by both genomic (classical and non-classical) and extra-nuclear signaling. Emerging evidence suggests that ERβ functions as a tissue-specific tumor suppressor with anti-proliferative actions. Recent studies have identified a number of naturally available selective ERβ agonists. Targeting ERβ using its naturally available ligands is an attractive approach for treating and preventing cancers. This review presents the beneficial actions of ERβ signaling and clinical utility of several natural ERβ ligands as potential cancer therapy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Glycine max
/
Extractos Vegetales
/
Química
/
Genisteína
/
Flavanonas
/
Usos Terapéuticos
/
Receptor beta de Estrógeno
/
Quimioterapia
/
Equol
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2015
Tipo del documento:
Artículo
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