Analgesic effects and structural elucidation of two new flavone C-glycosides from Artemisa sacrorum / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 786-790, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-812481
ABSTRACT
The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities of the isolated compounds were assessed in rats with hot plate test and paw pressure assay. Two new flavone C-glycosides, named as Sacroroside A and B (Compounds 1 and 2) were isolated from the EtOAc crude extract of the aerial parts ofArtemisa sacrorum Ledeb. They showed significant analgesic effects. In conclusion, Compounds 1 and 2 are new natural products, which show significant analgesic effects in a dose-dependent manner.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Dolor
/
Farmacología
/
Presión
/
Extractos Vegetales
/
Estructura Molecular
/
Química
/
Ratas Wistar
/
Artemisia
/
Componentes Aéreos de las Plantas
/
Flavanonas
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2015
Tipo del documento:
Artículo
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