A new γ-alkylated-γ-butyrolactone from the roots of Solanum melongena / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 699-703, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-812493
ABSTRACT
A new γ-alkylated-γ-butyrolactone, named melongenolide A (1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A (1), (+)-syringaresinol (2), (+)-lyoniresinol (3), 5,5'-dimethoxy lariciresinol (4), (+)-(7R,8R)-4-hydroxy-3,3',5'-trimethoxy-8',9'-dinor-8,4'-oxyneoligna-7, 9-diol-7'-aldehyde (5), kaempferol-3-O-(2″,6″-di-O-p-trans-coumaroyl)-β-glucoside (6), arjunolic acid (7), vanillic acid (8), scoparone (9), and β-sitosterol (10). Compounds 2, 6, and 7 showed potent inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages, with IC50 values being 5.62 ± 0.86, 11.47 ± 0.98, and 27.75 ± 1.26 μmol·L(-1), respectively.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Triterpenos
/
4-Butirolactona
/
Extractos Vegetales
/
Química
/
Lignanos
/
Raíces de Plantas
/
Concentración 50 Inhibidora
/
Solanum melongena
/
Quempferoles
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2015
Tipo del documento:
Artículo
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