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A new biflavone glucoside from the roots of Stellera chamaejasme / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 550-553, 2015.
Artículo en Inglés | WPRIM | ID: wpr-812511
ABSTRACT
The present study investigated the chemical constituents of the roots of Stellera chamaejasme (Thymelaeaceae). One new biflavone glucoside (1), along with other thirteen known compounds (2-14), was isolated by repeated column chromatographic methods and their structures were elucidated on the basis of spectral analyses. The cytotoxic activities of selected compounds were evaluated against four human cancer cell lines (A549, BEL-7402, HCT-116, and MDA-MB-231) by the SRB assay method. Compound 9 showed remarkable cytotoxicity against BEL-7402 with IC50 value being 0.65 μg·mL(-1); compounds 7, 8, and 12 exhibited significant cytotoxic activity against A549 with IC50 values being 2.38, 1.57, and 2.35 μg·mL(-1), respectively.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Extractos Vegetales / Estructura Molecular / Química / Raíces de Plantas / Concentración 50 Inhibidora / Thymelaeaceae / Línea Celular Tumoral / Biflavonoides / Usos Terapéuticos Límite: Humanos Idioma: Inglés Revista: Chinese Journal of Natural Medicines (English Ed.) Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Extractos Vegetales / Estructura Molecular / Química / Raíces de Plantas / Concentración 50 Inhibidora / Thymelaeaceae / Línea Celular Tumoral / Biflavonoides / Usos Terapéuticos Límite: Humanos Idioma: Inglés Revista: Chinese Journal of Natural Medicines (English Ed.) Año: 2015 Tipo del documento: Artículo