Diversity synthesis of tetrahydroprotoberberines glycosides by combined chemical and microbial catalysis / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 783-788, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-812557
ABSTRACT
The present study was designed to construct the structurally diverse library of tetrahydroprotoberberines (THPBs) by combining the methods of chemical nonselective demethylation and microbial glycosylation. HPLC-MS/MS analyses tentatively identified 12 de-methylated and 9 glycosylated derivates of THPBs and 5 rarely oxidized glycosides of THPBs in the library. Through this effort, we achieved not only a variety of the THPBs and their glycosides but also tested the catalytic characteristics and capabilities of G. deliquescens NRRL 1086.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Alcaloides de Berberina
/
Glicosilación
/
Biotransformación
/
Estructura Molecular
/
Catálisis
/
Química
/
Gliocladium
/
Glicósidos
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2016
Tipo del documento:
Artículo
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