Synthesis and in vitro cytotoxicity evaluation of baicalein amino acid derivatives / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 284-288, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-812691
ABSTRACT
AIM@#To synthesize the baicalein amino acid derivatives and evaluate their cytotoxicity activities in vitro.@*METHODS@#Amino acids were subjected to methylation and aminoacylation reaction, then reacted with formaldehyde and baicalein to synthesize baicalein-8 benzyl amino acid derivatives. Through carboxyl group protection and aminoacylation of amino acid and benzyl protection of baicalein, derivatives of baicalein-6-O-amino acid esters were obtained. All of the target compounds were identified by IR, MS and (1)H NMR.@*RESULTS@#Thirteen novel derivatives were synthesized and characterized. Their cytotoxic activities were assessed by the MTT method on the inhibition of HepG2 cells in vitro.@*CONCLUSION@#Compounds 4c, 4d, 7a and 7b showed a significant increase in cytotoxicity compared with baicalein.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Acilación
/
Estructura Molecular
/
Química
/
Flavanonas
/
Proliferación Celular
/
Toxicidad
/
Células Hep G2
/
Aminoácidos
/
Metilación
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2013
Tipo del documento:
Artículo
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