Synthesis of A B C-ring subunit of C-nor-D-homo-steroidal alkaloids: towards the total synthesis of cyclopamine / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 277-283, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-812692
ABSTRACT
A practical approach to the synthesis of the A, B and C-ring subunit of cyclopamine has been developed. This synthetic tactic highlights the utility of mandelate acetal-mediated resolution of the fused ring ketone (±)-4 and IBX-mediated oxidation cascades from 12 to 9. The availability of advanced intermediates from enantiomerically pure (+)-4 and 2 could provide efficient access to biologically active and structurally diverse C-nor-D-homo-steroidal alkaloids such as cyclopamine.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estereoisomerismo
/
Esteroides
/
Alcaloides de Veratrum
/
Estructura Molecular
/
Química
/
Fenómenos Químicos Orgánicos
/
Técnicas de Química Sintética
/
Métodos
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2013
Tipo del documento:
Artículo
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