Expressions of ERK and p-ERK in advanced prostate cancer / 中华男科学杂志
National Journal of Andrology
;
(12): 406-411, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-812752
ABSTRACT
Objective@#To investigate the expressions of extracellular signal-regulated kinase (ERK) and p-ERK in benign and malignant prostate tissues, and whether it can be used as a marker for the prognosis of advanced prostate cancer (PCa).@*METHODS@#Using immunohistochemical Envision, we detected the expressions of ERK1/2 and p-ERK1/2 in 20 cases of benign prostatic hyperplasia (BPH) and 40 cases of advanced PCa and analyzed their correlation with PCa metastasis, Gleason score, PSA level, and prognosis.@*RESULTS@#The expression of ERK1/2 was remarkably higher in the advanced PCa than in the BPH cases (82.5% vs 55%, P5 yr, and survival ≤ 5 yr groups were 61.9%, 89.5%, 57.9%, and 90.5%, respectively, with statistically significant differences among these groups (P<0.05).@*CONCLUSIONS@#ERK1/2 and p-ERK1/2 proteins are highly expressed in advanced PCa and p-ERK1/2 is associated with the metastasis and prognosis of advanced PCa.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Próstata
/
Hiperplasia Prostática
/
Neoplasias de la Próstata
/
Biomarcadores de Tumor
/
Mortalidad
/
Antígeno Prostático Específico
/
Proteína Quinasa 1 Activada por Mitógenos
/
Quinasas MAP Reguladas por Señal Extracelular
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
/
Masculino
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2017
Tipo del documento:
Artículo
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