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Expressions of JNK and p-JNK in advanced prostate cancer and their clinical implications / 中华男科学杂志
National Journal of Andrology ; (12): 309-314, 2017.
Artículo en Chino | WPRIM | ID: wpr-812768
ABSTRACT
Objective@#To investigate the expressions of JNK and p-JNK in advanced prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and their implications.@*METHODS@#Using immunohistochemistry, we detected the expressions of JNK and p-JNK proteins in 40 cases of paraffin wax-embedded PCa and 21 cases of BPH tissues and analyzed their relationships with advanced PCa and BPH as well as with the pathologic features of advanced PCa.@*RESULTS@#Statistically significant differences were not found in the positive expression rate of the JNK protein between BPH and PCa (42.86% vs 52.50%, P>0.05), non-metastatic and metastatic PCa (53.85% vs 51.85%, P >0.05), Gleason ≤7 and Gleason >7 (58.82% vs 47.82%, P >0.05), PSA ≤20 μg/L and PSA >20 μg/L (57.14% vs 51.52%, P >0.05), or survival >5 yr and survival ≤5 yr (60.00% vs 45.00%, P >0.05), nor in the expression level of p-JNK between BPH and PCa (33.33% vs 35.00%, P >0.05), non-metastatic and metastatic PCa (30.77% vs 37.03%, P >0.05), Gleason ≤7 and Gleason >7 (35.29% vs 34.78%, P >0.05), or PSA ≤20 μg/L and PSA >20 μg/L (43.75% vs 10.93%, P >0.05). However, the expression of p-JNK was significantly higher in the survival >5 yr than in the survival ≤5 yr group of the PCa patients (50.00% vs 20.00%, P <0.05).@*CONCLUSIONS@#PCa patients with highly expressed p-JNK have a longer survival time and the high positive rate of p-JNK is associated with the prognosis of PCa.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Pronóstico / Hiperplasia Prostática / Neoplasias de la Próstata / Inmunohistoquímica / Mortalidad / Antígeno Prostático Específico / Proteínas Quinasas JNK Activadas por Mitógenos / Clasificación del Tumor / Metabolismo Tipo de estudio: Estudio pronóstico Límite: Humanos / Masculino Idioma: Chino Revista: National Journal of Andrology Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Pronóstico / Hiperplasia Prostática / Neoplasias de la Próstata / Inmunohistoquímica / Mortalidad / Antígeno Prostático Específico / Proteínas Quinasas JNK Activadas por Mitógenos / Clasificación del Tumor / Metabolismo Tipo de estudio: Estudio pronóstico Límite: Humanos / Masculino Idioma: Chino Revista: National Journal of Andrology Año: 2017 Tipo del documento: Artículo