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Seminal plasma anti-Müllerian hormone and inhibin B and serum inhibin B in predicting the outcome of routine IVF fertilization / 中华男科学杂志
National Journal of Andrology ; (12): 991-996, 2017.
Artículo en Chino | WPRIM | ID: wpr-812844
ABSTRACT
Objective@#To analyze the correlations of seminal plasma (sp) anti-Müllerian hormone (spAMH) and inhibin B (spINHB) and serum INHB (serINHB) with semen parameters in oligoasthenospermia patients and explore their value in predicting the outcome of routine in vitro fertilization (IVF).@*METHODS@#We obtained the levels of spAMH, spINHB and serINHB as well as semen parameters from 88 infertile males undergoing IVF due to oligoasthenospermia or female uterine tubal factors from August 2016 to February 2017. Using the ROC curve and Pearson's correlation analysis, we examined the effects of the obtained parameters on the fertilization rate and assessed the correlation of the levels of spAMH, spINHB and serINHB with the semen parameters of the patients.@*RESULTS@#Concerning the predictive value for the outcome of IVF, Pearson's correlation analysis showed that the area under the ROC curve (AUC) of spAMH was 0.807 (sensitivity = 84.6%, specificity = 76%, cut-off point = 3.529, P <0.001) and that of spINHB was 0.768 (sensitivity = 84.6%, specificity = 88.7%, cut-off point = 31.117, P = 0.002). The serINHB level was found positively correlated with sperm concentration (r = 0.346, P = 0.001), total sperm count (r = 0.378, P <0.001), sperm motility (r = 0.521, P <0.001), and the percentage of progressively motile sperm (r = 0.343, P = 0.001).@*CONCLUSIONS@#The levels of spAMH and spINHB can be used as laboratory indexes to predict the fertilization rate of routine IVF and are correlated with semen parameters in oligoasthenospermia patients, while that of serINHB has a positive correlation with the semen parameters of the patients.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oligospermia / Semen / Recuento de Espermatozoides / Motilidad Espermática / Sangre / Fertilización In Vitro / Química / Curva ROC / Astenozoospermia / Hormona Antimülleriana Tipo de estudio: Estudio pronóstico Límite: Femenino / Humanos / Masculino Idioma: Chino Revista: National Journal of Andrology Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oligospermia / Semen / Recuento de Espermatozoides / Motilidad Espermática / Sangre / Fertilización In Vitro / Química / Curva ROC / Astenozoospermia / Hormona Antimülleriana Tipo de estudio: Estudio pronóstico Límite: Femenino / Humanos / Masculino Idioma: Chino Revista: National Journal of Andrology Año: 2017 Tipo del documento: Artículo