Progress in the study of macrophage activation and ulcerative colitis from the Notch/NF-κB/NLRP3 signaling pathway / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1174-1178, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-813033
ABSTRACT
Ulcerative colitis is an intestinal inflammatory disease characterized by diarrhea, abdominal pain and purulent stool. Uncontrolled inflammation caused by macrophage hyper-activation is an important cause of ulcerative colitis. Therefore, inhibiting macrophage hyper-activation is an effective way to treat ulcerative colitis. Notch signaling pathway is involved in regulating the immune response of macrophages and promoting inflammation. NF-κB signaling pathway is the "star pathway" involved in inflammation. NLRP3 inflammatory body is involved in the activation of macrophages. Notch, NF-κB and NLRP3 inflammatory bodies constitute the upstream and downstream signal pathways in the existing immune inflammatory diseases. Notch signal pathway can regulate the activation of macrophage via NF-κB/NLRP3 inflammatory body signaling pathway.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Transducción de Señal
/
Colitis Ulcerosa
/
Citocinas
/
FN-kappa B
/
Receptores Notch
/
Proteína con Dominio Pirina 3 de la Familia NLR
/
Activación de Macrófagos
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2019
Tipo del documento:
Artículo
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