Research progress of copper transporter 1 in platinum-based chemotherapy / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1376-1379, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-813123
ABSTRACT
Platinum drugs are widely used in the treatment of various solid tumors, but their resistance to platinum is the most significant obstacle to successful treatment. Copper transporter 1 (CTR1) is the specific transporter for copper, and it mainly locates at the plasma membrane and plays a role in pumping copper into the cell. CTR1 is also the major platinum influx transporter and plays a key role in platinum resistance. The expression, polymorphism, and degradation of CTR1 affect platinum resistance in tumors. Therefore, CTR1 may be a potential predictive biomarker of platinum resistance and a therapeutic target for overcoming platinum resistance.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Platino (Metal)
/
Investigación
/
Cisplatino
/
Resistencia a Antineoplásicos
/
Cobre
/
Proteínas de Transporte de Catión
/
Usos Terapéuticos
/
Transportador de Cobre 1
/
Genética
/
Metabolismo
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2018
Tipo del documento:
Artículo
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