Sensitivity of nanoparticlized cefazolin sodium to the bacteria in vitro / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To investigate whether the in vitro sensitivity of cefazolin sodium to the bacteria was altered after nanoparticlization.@*METHODS@#The minimal inhibitory concentrations (MIC) of cefazolin sodium before and after nanoparticlization to S. aureaus and E. coli. were determined by microdilution.@*RESULTS@#The MIC of nanoparticlized cefazolin sodium to S. aureaus and E. coli. had no significant change compared with that of non-nanoparticlized one.@*CONCLUSION@#Nanoparticlization will not decrease the sensitivity of cefazolin sodium to the bacteria.