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Myeloperoxidase in the plasma of patients with acute coronary syndrome / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 901-905, 2006.
Artículo en Chino | WPRIM | ID: wpr-813576
ABSTRACT
OBJECTIVE@#To determine the diagnostic value and efficacy for risk stratification of myeloperoxidase (MPO) levels in patients with acute coronary syndrome (ACS).@*METHODS@#One hundred and sixty-two patients were enrolled in this study. All patients underwent coronary angiography. They were divided into 3 groups ACS group (n=54), SAP group (n=54) and control group (n=54). Blood samples were taken from the artery before angiography in all patients and the concentrations of MPO, hsCRP and cTnI were measured. Each subject was asked details of history of hypertension, hyperlipidemia, diabetes and smoking habits. The efficacy of therapy, the cardiovascular events (myocardial infarction, the need for revascularization, or death) were recorded after 6 months of follow-up.@*RESULTS@#The plasma MPO level in ACS group (30.98 ng/mL) was significantly higher than those in the SAP group (14.67 ng/mL) and the control group(14.23 ng/mL)(P<0.01), and the plasma MPO levels in patients of the SAP group and the control group were not significantly different (P=0.74). There was no obvious correlation between the levels of plasma MPO and the serum levels of cTnI, hsCRP,the prevalence of the 4 major risk factors for CHD. Multivariate logistic regression analysis showed that plasma MPO level, free plasma glucose and sex were the significant variables. The risk for subsequent cardiovascular events was higher in the patients with elevated level of MPO.@*CONCLUSION@#Plasma MPO may be a new risk biomarker for ACS and may predict the incidence of subsequent cardiovascular events.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sangre / Biomarcadores / Estudios de Casos y Controles / Estudios de Seguimiento / Peroxidasa / Estimación de Kaplan-Meier / Síndrome Coronario Agudo Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Central South University(Medical Sciences) Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sangre / Biomarcadores / Estudios de Casos y Controles / Estudios de Seguimiento / Peroxidasa / Estimación de Kaplan-Meier / Síndrome Coronario Agudo Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Central South University(Medical Sciences) Año: 2006 Tipo del documento: Artículo