Oxidative stress in nitroglycerin tolerance and treatment with 3,4,5,6-tetrahydroxyxanthone / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 650-654, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-813628
ABSTRACT
OBJECTIVE@#To determine the relationship between the nitroglycerin tolerance and the stimulation of radical oxygen species (ROS) production, and the therapeutical effect of 3,4,5,6-tetrahydroxyxanthone.@*METHODS@#Vasodilator responses to nitroglycerin were examined in the isolated thoracic aorta. The contents of ROS,and cGMP were determined in the cultured human umbilical vein endothelial cells.@*RESULTS@#3,4,5,6-tetrahydroxyxanthone could significantly reduce the inhibition of relaxation by nitroglycerin. 3,4,5,6-tetrahydroxyxanthone could significantly inhibit the ROS increase and increase the cGMP level.@*CONCLUSION@#Nitroglycerin tolerance is associated with the stimulation of ROS production,and the reversal of nitroglycerin tolerance with 3,4,5,6-tetrahydroxyxanthone is related to the reduction of ROS.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Aorta Torácica
/
Farmacología
/
Venas Umbilicales
/
Endotelio Vascular
/
Células Cultivadas
/
Nitroglicerina
/
Especies Reactivas de Oxígeno
/
Ratas Sprague-Dawley
/
Estrés Oxidativo
/
Biología Celular
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2006
Tipo del documento:
Artículo
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