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Progression of lipopolysaccharide signal pathway / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 141-145, 2006.
Artículo en Chino | WPRIM | ID: wpr-813746
ABSTRACT
Lipopolysaccharide (LPS) is the major constituents of the outer membrane of Gram-negative bacteria. LPS recognition and signal transmission are key events in the host defense reaction towards Gram-negative bacteria and are associated with many disorders. Multiple signaling pathways are involved in the response to LPS. With the help of LPS-binding protein and CD14, TLR4 binds with LPS, then recruits myeloid differentiation factor 88 and IL-1 receptor-associated kinase, and further phosphorylates and activates TNF receptor associated factor 6 (TRAF6). The activated TRAF6 leads to the activation of transcription factor NF-kappaB and MAP kinase's pathways that involves in LPS-induced cellular responses and the production of proinflammatory cytokines such as TNF-alpha, IL-6 and IL8.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Fisiología / Proteínas de Fase Aguda / Glicoproteínas de Membrana / Transducción de Señal / Proteínas Portadoras / Química / Lipopolisacáridos / FN-kappa B / Receptores de Lipopolisacáridos Idioma: Chino Revista: Journal of Central South University(Medical Sciences) Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Fisiología / Proteínas de Fase Aguda / Glicoproteínas de Membrana / Transducción de Señal / Proteínas Portadoras / Química / Lipopolisacáridos / FN-kappa B / Receptores de Lipopolisacáridos Idioma: Chino Revista: Journal of Central South University(Medical Sciences) Año: 2006 Tipo del documento: Artículo