Immune tolerance induced by combined heart-thymus transplantation with intrathymic inoculation of thymocytes in rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 85-90, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-813760
ABSTRACT
OBJECTIVE@#To explore the role of allo heart and thymus transplantation by intrathymic inoculation of thymocytes.@*METHODS@#Wistar recipients were given intrathymic injection of allo thymocytes (2 x 10(7)) 14 days before the heart and/or thymus transplantation. Graft survival, histopathology, levels and mRNA expressions of IL-2, IL-4 in serum and cardiac-grafts were investigated.@*RESULTS@#Heart transplantation and heart-thymus composite transplantation with the treatment of CysA for 7 or 14 days prolonged graft survival. Heart transplantation and heart-thymus composite transplantation with intrathymic thymocytes injection induced the long-term survival of allo-grafts transiently immunosuppressed with CysA; IL-4 maintained at high levels but IL-2 kept at low levels in grafts in long-term survivals.@*CONCLUSION@#Intrathymic inoculation of allo thymoctyes can induce immune tolerance for both cardiac transplantation and heart-thymus combined transplantation in rats. Thymus graft may play a role in the induction and maintenance of central tolerance.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Timo
/
Trasplante
/
Sangre
/
Trasplante de Corazón
/
Interleucina-4
/
Interleucina-2
/
Ratas Wistar
/
Ratas Sprague-Dawley
/
Trasplante de Células
/
Biología Celular
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2006
Tipo del documento:
Artículo
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