Bcl-2, TGFbeta1, and apoptosis in placenta tissues in patients with hypertensive disorder complicating pregnancy / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 883-889, 2007.
Article
en Zh
| WPRIM
| ID: wpr-813782
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To determine the apoptosis in placenta tissues of patients with hypertensive disorder complicating pregnancy and its relationship with Bcl-2, TGFbeta1, and to explore the etiology of hypertensive disorder complicating pregnancy.@*METHODS@#Forty-five placenta samples were obtained from pregnancies with hypertensive disorder (15 gestational hypertension, 15 mild preeclampsia, and 15 severe preeclampsia) and 45 normal placenta tissues were enrolled from the third-trimester pregnancies. Immunohistochemistry (SP method) was used to study the expression of Bcl-2 and TGFbeta1 in human trophoblasts. Terminal deoxynucleotidyl transferase-dUTP nick end-labeling (TUNEL) was used to quantify the incidence of apoptosis in human trophoblasts.@*RESULTS@#The apoptosis rate and TGFbeta1 expression in hypertensive disorder complicating pregnancy group was higher than that in the control group, but the Bcl-2 expression was significantly lower than the control group (all Ps<0.01). With the aggravation of this illness, the apoptosis rate and TGFbeta1 expression in the gestational hypertension group, mild preeclampsia group, and severe preeclampsia tended to be increasing, but the Bcl-2 expression was decreasing (P<0.001). The apoptosis of placenta villi and TGFbeta1 expression were positively correlated in the severe preeclampsia group and mild preeclampsia group,but the apoptosis of placenta villi and Bcl-2 were negatively correlated (all Ps<0.05). TGFbeta1 and Bcl-2 expressions in the severe preeclampsia group and mild preeclampsia group were negatively correlated (P<0.05).@*CONCLUSION@#Apoptosis of the placental trophoblasts of pregnancies with hypertensive disorder is evidently enhanced. The TGFbeta1 expression increases and the Bcl-2 expression decreases. The imbalance between TGFbeta1 and Bcl-2 expression may induce the hypertensive disorder.
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1
Índice:
WPRIM
Asunto principal:
Placenta
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Tercer Trimestre del Embarazo
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Apoptosis
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Proteínas Proto-Oncogénicas c-bcl-2
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Biología Celular
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Hipertensión Inducida en el Embarazo
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Factor de Crecimiento Transformador beta1
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Metabolismo
Límite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Año:
2007
Tipo del documento:
Article