Genomic instability in nasopharyngeal carcinoma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 417-421, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-813869
ABSTRACT
OBJECTIVE@#To evaluate the effect of genomic instability on prognostics in nasopharyngeal carcinoma.@*METHODS@#Genomic instability was assessed by inter-simple sequence repeats polymerase chain reaction (inter-SSR PCR) in 38 patients with nasopharyngeal carcinoma. Characterization and verification of band alterations shared in different tumors were carried out by sequencing and nest PCR.@*RESULTS@#Thirty-one (81.6%) of the 38 patients showed genomic altercations, and genomic instability index ranged 0 to 16.2 percent. A gain-based genomic damage shared in 6 tumors was identified on chromosome 6q27. Genomic alteration was significantly more in patients less than 5-year survival than those with more than 5-year survival (P<0.05).@*CONCLUSION@#Genomic instability can be an early event marker in carcinogenesis of nasopharyngeal carcinoma. Aggravation of genomic alterations is a poor prognosis for cancer recovery.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Cromosomas Humanos Par 3
/
Cromosomas Humanos Par 6
/
Análisis Mutacional de ADN
/
Datos de Secuencia Molecular
/
Secuencia de Bases
/
Análisis de Supervivencia
/
Neoplasias Nasofaríngeas
/
Reacción en Cadena de la Polimerasa
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2007
Tipo del documento:
Artículo
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