Spontaneous abortion and changes of estrogen receptors and progesterone receptors in the endometria of patients with polycystic ovary syndrome / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 518-522, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-814046
ABSTRACT
OBJECTIVE@#To explore the relationship between the spontaneous abortion and changes of estrogen receptors (ER) and progesterone receptors (PR) in the endometria of patients with polycystic ovary syndrome (PCOS).@*METHODS@#Thirty-two patients who suffered PCOS combined with infertilitas feminis were enrolled in a experimental group,and 20 patients with tubal infertilitas feminis having the corresponding time period as a control group. The expressions of ER and PR in the endometria were observed by pathological examination and immunohistochemical staining.@*RESULTS@#The expressions of ER and PR in the glands and interstitium of endometrial in the PCOS group were significantly lower than those of the tubal infertilitas feminis group (P=0.004,P=0.001). The expressions of ER and PR in the PCOS group in the glands organ and interstitium of endometrial among 3 different periods were not significantly different (P>0.05). The expressions of ER in the glands of endometrium in the spontaneous abortion group were significantly lower than those of the non-spontaneous abortion group (P=0.02), but there was no statistical difference between the two groups in the interstitium of endometria (P>0.05). The expression of PR in the glands interstitium of endometria showed no statistical difference between the spontaneous abortion group and the non-spontaneous abortion group (P>0.05).@*CONCLUSION@#The decrease of ER and PR of endometrial in the PCOS patients, may be a reason for spontaneous abortion, and the cyclical irregularity of ER and PR in the PCOS patients is another cause of spontaneous abortion.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Síndrome del Ovario Poliquístico
/
Receptores de Progesterona
/
Receptores de Estrógenos
/
Aborto Espontáneo
/
Endometrio
/
Metabolismo
Límite:
Adulto
/
Femenino
/
Humanos
/
Embarazo
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2008
Tipo del documento:
Artículo
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