Protection of cadaver lungs of non-heart-beating donor lung transplantation in rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 353-358, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-814071
ABSTRACT
OBJECTIVE@#To investigate the methods to alleviate lung injury of non-heart-beating donor to attain better structure and function.@*METHODS@#Sixty-four Sprague-Dawley rats were randomly divided into 4 groupsú a heart-beating donor group(HBD group), a non-heart-beating donor group without protective measures(NHBD-N group), a non-heart-beating donor group with continuous mechanical ventilation or with topical cooling on cadaver lung (NHBD-V group and NHBD-I group). After the transplantation, lung compliance,pulmonary function,wet/dry ratio of lung and content of energy metabolism were compared among the 4 groups.@*RESULTS@#Due to the longer warm ischemic period, NHBD lungs suffered more injuries than HBD lungs. However, compared with NHBD-N group, the wet/dry ratio of the lung in NHBD-V group and NHBD-I group was lower(5.28+/-1.24,4.21+/-0.85,4.14+/-1.33,P<0.01),the lung injury index (14.35+/-3.21,11.28+/-3.26,10.41+/-2.85, P<0.01)and the count of white blood cells(425.60+/-86.47,316.30+/-56.24,295.50+/-70.26, P<0.01) were milder, while the lung compliance and preservation of energetic metabolte were better in the NHBD-V group and the NHBD-I group.@*CONCLUSION@#Continuous mechanical ventilation or topical cooling may protect the NHBD lung during the warm ischemic period.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Preservación de Órganos
/
Factores de Tiempo
/
Donantes de Tejidos
/
Cadáver
/
Distribución Aleatoria
/
Rendimiento Pulmonar
/
Trasplante de Pulmón
/
Ratas Sprague-Dawley
/
Paro Cardíaco
/
Pulmón
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2008
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS