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Association of metabolic syndrome with serum interleukin-10 and high sensitive C reactive protein(hs-CRP) in old men / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 970-974, 2008.
Artículo en Chino | WPRIM | ID: wpr-814166
ABSTRACT
OBJECTIVE@#To explore the association of metabolic syndrome(MS) with serum interleukin-10 (IL-10) and high sensitive C reactive protein(hs-CRP) in old men with MS.@*METHODS@#Seventy patients with MS and 30 age-matched controls were enrolled. Blood pressure, waist circumference(WC), weight, height, body mass index(BMI), lipid-profile, fasting plasma glucose(FPG), fasting plasma insulin (FINS), homeostasis model assessment of insulin resistance(HOMA-IR),the serum IL-10, and hs-CRP levels were measured. The concentration of serum IL-10 was measured by enzyme linked immunosorbent assay (ELISA), and serum hs-CRP level by the latex-enhanced immuno- turbidimetric assay.@*RESULTS@#Compared with the control group, the serum IL-10 level in the MS group was significantly lower (P<0.05), and the concentration of hs-CRP was obviously higher (P<0.05). Using Pearson's correlation analysis, the serum IL-10 level was negatively related with HOMA-IR(r=-0.684,P=0.000)and FINS(r=-0.742,P=0.000); hs-CRP was positively related with BMI(r=0.372,P=0.002), HOMA-IR(r=0.276,P=0.021)and FINS(r=0.312,P=0.008)in the MS group. Stepwise regression analysis suggested that FINS might be the influencing factors of IL-10; BMI and FINS might be the influencing factors of hs-CRP in patients with MS.@*CONCLUSION@#In old male patients with MS, the concentration of serum IL-10 decreases, and the serum hs-CRP level increases obviously. This suggests chronic inflammation.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sangre / Proteína C-Reactiva / Ensayo de Inmunoadsorción Enzimática / Interleucina-10 / Síndrome Metabólico / Inflamación / Metabolismo Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Límite: Anciano / Humanos / Masculino Idioma: Chino Revista: Journal of Central South University(Medical Sciences) Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sangre / Proteína C-Reactiva / Ensayo de Inmunoadsorción Enzimática / Interleucina-10 / Síndrome Metabólico / Inflamación / Metabolismo Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Límite: Anciano / Humanos / Masculino Idioma: Chino Revista: Journal of Central South University(Medical Sciences) Año: 2008 Tipo del documento: Artículo