Primary study of resting state functional magnetic resonance imaging in early onset schizophrenia using ReHo / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 947-951, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-814374
ABSTRACT
OBJECTIVE@#To explore the regional homogeneity of resting state brain activity in early onset schizophrenia using functional magnetic resonance imaging.@*METHODS@#Schizophrenia or schizophreniform disorder was diagnosed according to DSM-IV-TR (diagnostic and statistical manual of mental disorders, fourth edition, text revision). A total of 18 adolescents with early-onset schizophrenia (EOS; onset of psychotic symptoms by age 18) and 18 age- and gender-matched healthy volunteers were tested in a resting-state fMRI scan. Regional homogeneity approach was used to analyze the functional imaging data,and statistical parametric mapping 5 (SPM5)was used to perform t-test in ReHo maps between the patients and controls.@*RESULTS@#In comparison with the controls, the early-onset patients showed significantly decreased regional homogeneity in bilateral medial prefrontal cortex(P20), but no brain regions showed significantly increased regional homogeneity in the patients.@*CONCLUSION@#Regional homogeneity of resting state brain activities in EOS was decreased in bilateral medial prefrontal cortex. These abnormal changes may be involved in the psychopathology of schizophrenia.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Esquizofrenia
/
Factores de Tiempo
/
Encéfalo
/
Imagen por Resonancia Magnética
/
Estudios de Casos y Controles
/
Corteza Prefrontal
/
Métodos
Tipo de estudio:
Guía de Práctica Clínica
/
Estudio observacional
Límite:
Adolescente
/
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2010
Tipo del documento:
Artículo
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