Efficacy of sequential therapy with pantoprazole in gastro esophageal reflux disease / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To observe the clinical efficacy of sequential therapy with pantoprazole in patients with gastro esophageal reflux disease (GERD).@*METHODS@#A total of 80 patients with GERD were double-blindedly randomized into 2 groups 40 patients received sequential therapy with pantoprazole 40 mg injection, twice daily for 2 weeks, and then pantoprazole 40 mg oral administration,twice daily for 2 weeks; the other 40 patients received pantoprazole 40 mg oral administration alone,twice daily for 4 weeks. Doctors and patients recorded the severity and frequency of heartburn before and during the treatment. The curative effects of the 2 groups were compared.@*RESULTS@#The total effective rate in the sequential therapy group was higher than that of the oral administration group(95.0% vs 77.5%, P<0.05).@*CONCLUSION@#Pantoprazole sequential therapy is effective for GERD.