Inflammatory factors promote the development of colorectal cancer / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To study the change of inflammatory factors at different stages of colorectal cancer (CRC).@*METHODS@#Thirty normal subjects, 30 patients with colorectal adenomatous polyps and 120 CRC patients at different stages were enrolled. IgG, IgM, and IgA levels, the inflammatory cytokines IL-2, 4, 6, 10, and 12 and the expression of TGF-β 1 and VEGF in the serum were analyzed by ELISA or immunoturbidimetry.@*RESULTS@#The serum concentrations of IL-12, TGF-β 1, and IL-6 in the CRC patients were statistically different compared with the normal and adenomatous polyps, and increased as the disease progressed (P0.05). The serum level of IgG, IgM, and IgA in the 3 groups showed no significant difference (P>0.05).@*CONCLUSION@#The serum level of inflammatory cytokines TGF-β 1, IL-6, and IL-12 increases gradually with the development of CRC, which may change the microcirculation of patients with CRC, and promote the development of CRC.