Developments in the study of CD40/ CD40L gene and its polymorphism in atherosclerosis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 413-418, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-814656
ABSTRACT
CD40/CD40L is a pair of complementary transmembrane glycoproteins, expressed on immune cells, endothelial cells, smooth muscle cells, platelets and other cells involved in regulation of immunity, inflammation, coagulation and other pathophysiologic states. A large number of researches have demonstrated that, when atherosclerosis occurs, CD40L ligates CD40; subsequently CD40 is activated and stimulates downstream signaling pathways, including nuclear factor-kappaB, with consequent up-regulation of proinflammatory and proatherogenic genes. Thus it plays an important role in the occurrence, development and plaque-rupture of atherosclerosis. CD40/CD40L is a bridge between immunity, inflammation, and a hypercoagulable state, and may be an important target for prevention and treatment of cardiovascular disease.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Polimorfismo Genético
/
FN-kappa B
/
Antígenos CD40
/
Trombofilia
/
Ligando de CD40
/
Aterosclerosis
/
Genética
/
Inmunidad
/
Inflamación
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2012
Tipo del documento:
Artículo
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