Expression of ADAMTS-2 and TGF-β1 in cirrhotic liver / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1026-1030, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-814746
ABSTRACT
OBJECTIVE@#To explore the expression and distribution of a disintegrin and metalloprotease with thrombospondin motif (ADAMTS)-2 and transforming growth factor (TGF) -β1 in patients with or without cirrhosis, and to determine their relation.@*METHODS@#The liver tissues from 16 patients with cirrhotic portal hypertensive and 8 patients with liver injury were collected in Wuhan General Hospital from March to June, 2010. Immunohistochemistry and Western blot were applied to detect the protein expression of ADAMTS-2 and TGF-β1.@*RESULTS@#Immunohistochemistry showed that the expression of ADAMTS-2 and TGF-β1 was significantly higher in the cirrhotic tissues than that in normal tissues (P<0.05). Western blot also showed the expression of ADAMTS-2 and TGF-β1 in the cirrhosis tissues was significantly higher than that in normal tissues (P<0.05). There was a positive correlation between ADAMTS-2 and TGF-β1 (r=0.862, P<0.01).@*CONCLUSION@#ADAMTS-2 and TGF-β1 may have a synergistic reaction in promoting liver cirrhosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Procolágeno N-Endopeptidasa
/
Inmunohistoquímica
/
Western Blotting
/
Proteínas ADAM
/
Factor de Crecimiento Transformador beta1
/
Proteínas ADAMTS
/
Proteína ADAMTS4
/
Hígado
/
Cirrosis Hepática
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2012
Tipo del documento:
Artículo
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