Expression of galectin-7 and S100A9 and development of cervical squamous carcinoma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 888-895, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-814827
ABSTRACT
OBJECTIVE@#To observe the correlation between the expression of galectin-7 and S100A9 with the development of cervical squamous carcinoma.@*METHODS@#Immunohistochemical SP staining was used to detect the expression of galectin-7 and S100A9 in 243 patients with cervical intraepithelial neoplasia (CIN) or cervical squamous carcinoma. The association of clinical data with galectin-7 and S100A9 expression was examined.@*RESULTS@#The expression of galectin-7 and S100A9 in CIN and cervical squamous carcinoma was significantly different (P0.05). Expression of galectin-7 was associated with the survival rate of patients with cervical squamous carcinoma (P<0.05). Univariate analysis of Cox proportional hazards regression model revealed that the FIGO stage, lymph nodes metastasis, and the expression of galectin-7 were relevant to the 5 year survival rate of patients with cervical squamous carcinoma, which was confirmed by multiple analysis of Cox proportional hazards regression model.@*CONCLUSION@#Expression of galectin-7 and S100A9 is related with cervical the tumorigenesis of carcinoma, clinical stage, and lymph nodes of cervical squamous carcinoma. Galectin-7 is probably associated with the prognosis. The long-term survival of patients with cervical carcinoma may be associated with FIGO stage, lymph node metastasis, and the expression of galectin-7.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Carcinoma de Células Escamosas
/
Modelos de Riesgos Proporcionales
/
Diferenciación Celular
/
Displasia del Cuello del Útero
/
Neoplasias del Cuello Uterino
/
Tasa de Supervivencia
/
Calgranulina B
/
Galectinas
/
Metástasis Linfática
Tipo de estudio:
Estudio pronóstico
Límite:
Femenino
/
Humanos
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2013
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS