Expression of autoantibody against the M2-muscarinic receptor in patients with severe preeclampsia / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To test the expression of autoantibody against the M2-muscarinic receptor in patients with severe preeclampsia.
@*METHODS@#A case-control study, including 78 patients with severe preeclampsia and 78 women with normal pregnancy in Department of Gynaecology and Obstetrics of Capital Medical University affiliated Beijing Chao-Yang Hospital from Jan, 2013 to Jan, 2015, were conducted, and 60 non-pregnant women were served as a control group. ELISA protocol was used to test serum autoantibody against the M2-muscarinic receptor. The clinical significance of the autoantibody against the M2-muscarinic receptor among women with severe preeclampsia was estimated.
@*RESULTS@#Autoantibody against the M2-muscarinic receptor were positive in 32.1% (25/78) of patients with severe preeclampsia, in 10.3% (8/78, P<0.05) of normal pregnant women and in 8.3% (5/60, P<0.05) of non-pregnant controls. The concentration of creatine kinase in patients with severe preeclampsia and normal pregnant women were (101.49±142.75) and (57.94±31.64) U/L,
respectively. Mask difference exist between the severe preeclampsia group and the normal pregnancy group (P<0.05).
@*CONCLUSION@#The expression of autoantibody against the M2-muscarinic receptor in patients with severe preeclampsia is elevated significantly, which is associated with severe preeclampsia. However, its etiological role needs further to be investigated.