Hyperuricemia is an independent risk factor for
renal pathological damage and poor prognosis in
lupus nephritis patients / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1052-1057, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-815134
ABSTRACT
To explore the correlation between hyperuricemia and renal damage in patients with lupus nephritis (LN).
Methods:
The data for clinical features, laboratory and renal pathological examination were collected from 177 renal biopsy-proven LN patients with or without hyperuricemia and were retrospectively analyzed to determine the correlation between serum uric acid and renal damage.Results:
LN patients with hyperuricemia group had higher rate of hypertension and higher level of blood urea nitrogen and serum creatinine while lower estimated glomerular filtration rate (eGFR) and lower positive rate of anti-U1RNP antibody (P<0.05). In the LN patients with hyperuricemia group, renal pathological scores, including acitive index, chronic index and tubulointerstitial lesions, were higher than those in the LN patients without hyperuricemia group (P<0.05). The level of serum uric acid was positively correlated with serum creatinine, renal pathological classification and renal pathological scores while negatively correlated with eGFR (P<0.05).Conclusion:
LN patients with hyperuricemia are associated with more serious renal damage. Hyperuricemia is an important predictor for poor prognosis in patients with LN.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fisiología
/
Pronóstico
/
Ácido Úrico
/
Sangre
/
Nitrógeno de la Urea Sanguínea
/
Nefritis Lúpica
/
Epidemiología
/
Estudios Retrospectivos
/
Factores de Riesgo
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Journal of Central South University(Medical Sciences)
Año:
2016
Tipo del documento:
Artículo
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