Expression of PTEN, p53 and EGFR in the molecular subtypes of breast carcinoma and
the correlation among them / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 973-978, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-815240
ABSTRACT
OBJECTIVE@#To study the expression of PTEN, p53 and epidermal growth factor receptor (EGFR) in the molecular subtypes of breast carcinoma and to evaluate the correlations with triple-negative breast cancer.
@*METHODS@#Immunohistochemical MaxVision(TM) method was used to detect the expression of PTEN, p53, EGFR, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) in 291 cases of infiltrating ductal carcinoma of breast.
@*RESULTS@#The positive expression of PTEN, p53 and EGFR protein in breast carcinoma was 57.0%, 57.0% and 38.5%, respectively, which were significantly different from those in benign breast diseases (P<0.05). The expression of PTEN or EGFR in breast cancer was correlated with tumor size, histological grade, lymph node metastasis, TNM stage, ER and HER2 status (P<0.05); the expression of p53 was correlated with tumor size, histological grade and ER status (P<0.05). The difference of positive expression rates of PTEN, p53 and EGFR protein among different subtypes including luminal A, luminal B (HER2-), luminal B (HER2+), HER2 over-expression and triple-negative was statistically significant (P<0.05). There were close correlations among PTEN, p53 and EGFR in the triple-negative subtype (P<0.05).
@*CONCLUSION@#Low expression of PTEN and high expression of EGFR and p53 are observed in triple-negative breast cancer, which may synergistically contribute to the pathogenesis of triple-negative breast cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Neoplasias de la Mama
/
Receptores de Progesterona
/
Receptores de Estrógenos
/
Proteína p53 Supresora de Tumor
/
Clasificación
/
Carcinoma Ductal de Mama
/
Receptor ErbB-2
/
Fosfohidrolasa PTEN
/
Neoplasias de la Mama Triple Negativas
Límite:
Femenino
/
Humanos
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2015
Tipo del documento:
Artículo
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