WEE1, histone and tumor / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 806-810, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-815267
ABSTRACT
WEE1 is an important factor for histone transcription, chromosome condensation and regulation of cell cycle progression. WEE1 kinase can phosphorylate Cdc2 and down-regulate Cdc2 kinase activity. It can regulate G2 to M phase transition and cell mitosis. It plays a key role in chromosome condensation delay and histone synthesis, suggesting the important functions of WEE1 in the occurrence and development in cancer. At present, a multiple WEE1 inhibitors have been discovered. A great progress has been made in combination of WEE1 inhibitors with DNA damage treatment (chemotherapy or radiotherapy), which makes WEE1 an important target in cancer treatment.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fosforilación
/
Daño del ADN
/
Proteínas Tirosina Quinasas
/
Proteínas Nucleares
/
Histonas
/
Ciclo Celular
/
Proteína Quinasa CDC2
/
Proteínas de Ciclo Celular
/
Metabolismo
/
Neoplasias
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2015
Tipo del documento:
Artículo
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