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Prognostic value of statin for cancer patients: 
A Meta-analysis / 中南大学学报(医学版)
Zhongnan Daxue xuebao. Yixue ban ; (12): 770-781, 2015.
Article en En | WPRIM | ID: wpr-815272
Biblioteca responsable: WPRO
ABSTRACT
OBJECTIVE@#To systematically evaluate the effect of statins on prognosis for patients with cancers.
@*METHODS@#Literature on PubMed, EMbase and Cochrane library was screened from the establishment of databases to March, 2015 to find relevant studies. Random-effects models were used to calculate the pooled hazard ratios (HR) and 95% confidence interval (CI) for the association between statin use and all-cause mortality and cancer-specific mortality.
@*RESULTS@#A total of 25 studies covered 523 193 patients were identified and included in this Meta-analysis. The pooled effect showed that statin application was associated with a reduction in all-cause mortality in cancer patients (HR, 0.82; 95% CI: 0.76 to 0.89). A significantly decreased mortality in prostate cancer was revealed in subgroup by cancer sites (HR, 0.66; 95% CI: 0.52 to 0.83). In addition, sensitivity analysis demonstrated a weakened association between statin application and all-cause mortality after excluding the studies with shorter follow-up duration (HR, 0.91; 95% CI: 0.75 to 1.10).
@*CONCLUSION@#A beneficial effect of statin on all-cause mortality and cancer-specific mortality is presented in patients with cancer. However, further studies are needed to confirm the long term effect.
Asunto(s)
Texto completo: 1 Índice: WPRIM Asunto principal: Pronóstico / Neoplasias de la Próstata / Mortalidad / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Usos Terapéuticos / Quimioterapia / Neoplasias Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Humans / Male Idioma: En Revista: Zhongnan Daxue xuebao. Yixue ban Año: 2015 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Pronóstico / Neoplasias de la Próstata / Mortalidad / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Usos Terapéuticos / Quimioterapia / Neoplasias Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Humans / Male Idioma: En Revista: Zhongnan Daxue xuebao. Yixue ban Año: 2015 Tipo del documento: Article