COMT genetic variation and clinical response to antipsychotic drug treatment: A Meta-analysis / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To examine the relationship between COMT polymorphisms and the response to antipsychotic drugs, and then provide a basis for personalized medicine of antipsychotic drugs.
@*METHODS@#We performed a systematic search from PubMed, Embase, Cochrane Library, CBM, CNKI, VIP and Wanfang database for eligible studies. Stata 12.0 was used for Meta-analysis after evaluating the quality of studies and collecting the data.
@*RESULTS@#Nine studies included 868 participants met inclusion criteria. Significant association was found between the COMT Val108/158Met gene polymorphism and antipsychotic drug efficacy. Evaluating the therapeutic efficacy through general symptoms Met vs Val, RR=1.18, 95% CI 1.04-1.35, P=0.013; Met/Met vs Val/Val, RR=1.40, 95% CI 1.08-1.82, P=0.010. Evaluating the therapeutic efficacy through negative symptoms Met vs Val, RR=1.24, 95% CI 1.05-1.46, P=0.013; Met/Met vs Val/Val, RR=1.60, 95% CI 1.04-2.46, P=0.031.
@*CONCLUSION@#COMT Val108/158Met gene polymorphism is significantly associated with antipsychotic drug efficacy, and Met gene is a dominant gene which displays a better response to antipsychotic drugs.