Association of VEGFR2 gene polymorphisms with the effect of L-dopa and dyskinesia complications / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1199-1204, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-815354
ABSTRACT
OBJECTIVE@#To explore the association of VEGFR2 gene polymorphisms (rs2305948 and rs1870377) with the effect of levodopa (L-dopa) and dyskinesia in Chinese population and to provide theoretical basis for clinical treatment.
@*METHODS@#By using Taqman MGB analysis and gene sequencing, the rs2305948 and rs1870377 polymorphisms of 69 enrolled Parkinson's disease (PD) patients were detected. Among them, 32 cases developed dyskinesia during 5 years and 37 cases did not develop dyskinesia during 8 years (as the control).
@*RESULTS@#There was no significant association between the occurrence of dyskinesia and VEGFR2 polymorphisms at rs2305948 and rs1870377. However, rs1870377 polymorphism of AA showed greater maximum L-dopa dose [(565.00±163.55) mg/d vs (396.88±200.39) mg/d, (300.00±80.18) mg/d, P=0.038] and higher value of Modified Abnormal Involuntary Movement Scale (mAIMS) compared with that with polymorphisms of AT and TT [17.00±5.24 vs 8.94±6.53, 7.86±4.45, P=0.026].
@*CONCLUSION@#VEGFR2 genes polymorphism (rs1870377) is associated with maximum L-dopa dose and mAIMS value in PD patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedad de Parkinson
/
Farmacología
/
Polimorfismo Genético
/
Levodopa
/
Receptor 2 de Factores de Crecimiento Endotelial Vascular
/
Quimioterapia
/
Genética
/
Antiparkinsonianos
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Central South University(Medical Sciences)
Año:
2015
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS