ANCA associated glomerulonephritis in a patient with mixed connective tissue disease / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 209-214, 2014.
Article
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| ID: wpr-815440
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WPRO
ABSTRACT
OBJECTIVE@#To investigate the diagnosis and treatment of mixed connective tissue disease (MCTD) and myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) associated vasculitis, which is a rare clinical entity in medical practice.@*METHODS@#A 35-year-old female of Asian origin was admitted to our hospital due to complaints of Raynaud's phenomenon, myalgia, arthralgia and fatigue. The patient was diagnosed as MCTD in the out-patient department 8 months prior to admission based on Alarcon-Segovia classification criteria of Raynaud's phenomenon, myalgia, arthralgia and a high anti-U1 ribonucleoprotein antibody level. Interstitial lung disease was determined by chest computed tomography. Renal biopsy was performed because of marked proteinuria on 24 h urine collection. Histopathological examination revealed glomerulonephritis with fibrocellular/cellular crescents, in which moderate staining of IgM was shown by direct immunofluorescence. She was tested positive for myeloperoxidase antineutrophil cytoplasmic antibody.@*RESULTS@#High dose of methylprednisolone (500 mg/d for 3 days) was started intravenously when the results of renal biopsy were obtained. Oral prednisone and intravenous cyclophosphamide therapy (0.8 g/month) were continued for 12 months. Daily urinary protein loss decreased dramatically and serum creatinine was maintained at a normal level.@*CONCLUSION@#Corticosteroids and cyclophosphamide are effective in the treatment of MPO-ANCA associated glomerulonephritis in MCTD.
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Asunto principal:
Proteinuria
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Metilprednisolona
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Peroxidasa
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Anticuerpos Anticitoplasma de Neutrófilos
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Ciclofosfamida
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Glomerulonefritis
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Enfermedad Mixta del Tejido Conjuntivo
Límite:
Adult
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Female
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Humans
Idioma:
En
Revista:
Journal of Central South University(Medical Sciences)
Año:
2014
Tipo del documento:
Article