Morphologic studies of the retina in a new diabetic model; SHR/N:Mcc-cp rat
Yonsei Medical Journal
;
: 453-462, 1998.
Artículo
en Inglés
| WPRIM
| ID: wpr-81584
ABSTRACT
The pathogenesis of diabetic retinopathy has not been fully explained. The earliest histological lesion is the loss of intramural pericytes and thickening of the basement membrane. Increased activity of the polyol pathway is a probable mechanism for these two abnormalities. Investigations have suffered from the lack of an exact animal model simulating the human condition. Examination of the retina in the spontaneously diabetic SHR/NMcc-cp rat demonstrated degeneration and loss of intramural pericytes, a progressive increase in basement membrane thickness, and microinfarctions with an area of non-perfusion. Therefore, this model may be used to clarify the biochemical mechanisms linking the metabolic abnormalities of diabetes and retinopathy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ratas Endogámicas SHR
/
Ratas Endogámicas
/
Retina
/
Degeneración Retiniana
/
Retinopatía Diabética
/
Modelos Animales de Enfermedad
/
Animales
Límite:
Animales
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
1998
Tipo del documento:
Artículo
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