Application prospect of complete biodegradable occluder in congenital heart disease / 中国实用内科杂志

ABSTRACT

Congenital heart disease(CHD)is one of the most common cardiovascular diseases in children, which ranks the first place of birth defects and severely threatens human health. With the developments of medical apparatus and progress of medical technology,interventional therapy has already become the preferred therapeutic choice for certain types of CHD including atrial septal defect,ventricular septal defect and patent ductus arteriosus, etc. However, occluders currently used are made of NiTi, which exist permanently in human body after implantation. Generally, the surface endothelialization of occluders makes them lose its significance of existence 6 months after implantation. Ideal occluders should gradually undergo self-degradation till they vanish, thus avoiding the permanent existence of metal materials. Nowadays, with the development of medical materials, such an idea has become possible.