Safety of prophylactic HPV vaccine:a systematic review / 中国实用妇科与产科杂志
Chinese Journal of Practical Gynecology and Obstetrics
;
(12): 827-832, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-816260
ABSTRACT
OBJECTIVE:
To systematically review the safety of HPV vaccine among healthy women.METHODS:
Primary literature was retrieved from PubMed,CNKI and CBM.Data were searched for randomized controlled trials(RCTs)about safety of HPV vaccine from inception to December 2018.Two investigators screened literature according to the inclusion and exclusion criteria,extracted data,and assessed methodological quality of included studies independently.RESULTS:
Totally 16 studies,17 RCTs and 75164 participants were included. A higher incidence of solicited injection-site symptoms(pain,redness)was observed in the vaccine group compared to control group,but these symptoms were tolerable and self-cured.General solicited symptoms(headache,fatigue,etc.)were slight,and there was no significant difference in the incidence between the two groups.Serious adverse events were similar in both groups,and pregnancy outcomes did not differ between the two groups.CONCLUSION:
The three types of prophylactic HPV vaccine are safe.The main adverse event is local symptom,which is well tolerated,so the vaccines can be safely used.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Ensayo Clínico Controlado
/
Revisiones Sistemáticas Evaluadas
Idioma:
Chino
Revista:
Chinese Journal of Practical Gynecology and Obstetrics
Año:
2019
Tipo del documento:
Artículo
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