Recent Improvements in Genomic and Transcriptomic Understanding of Anaplastic and Poorly Differentiated Thyroid Cancers
Endocrinology and Metabolism
;
: 44-54, 2020.
Artículo
en Inglés
| WPRIM
| ID: wpr-816630
ABSTRACT
Anaplastic thyroid cancer (ATC) is a lethal human cancer with a 5-year survival rate of less than 10%. Recently, its genomic and transcriptomic characteristics have been extensively elucidated over 5 years owing to advance in high throughput sequencing. These efforts have extended molecular understandings into the progression mechanisms and therapeutic vulnerabilities of aggressive thyroid cancers. In this review, we provide an overview of genomic and transcriptomic alterations in ATC and poorly-differentiated thyroid cancer, which are distinguished from differentiated thyroid cancers. Clinically relevant genomic alterations and deregulated signaling pathways will be able to shed light on more effective prevention and stratified therapeutic interventions for affected patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Glándula Tiroides
/
Neoplasias de la Tiroides
/
Tasa de Supervivencia
/
Genoma
/
Secuenciación de Nucleótidos de Alto Rendimiento
/
Transcriptoma
/
Carcinoma Anaplásico de Tiroides
Límite:
Humanos
Idioma:
Inglés
Revista:
Endocrinology and Metabolism
Año:
2020
Tipo del documento:
Artículo
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