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Study on the Separation and Purification Technology of Total Flavonoids from Sparganium stoloni by Box-Behnken Design- response Surface Methodology / 中国药房
China Pharmacy ; (12): 1502-1506, 2019.
Artículo en Chino | WPRIM | ID: wpr-816914
ABSTRACT
OBJECTIVE: To optimize the purification technology of total flavonoids from Sparganium stoloniferum. METHODSSeparation and purification by macroporus adsorption resin, using sample solution pH, flow rate and concentration of eluent, the purification rate of total flavonoids as evalution indexes, the purification technology of total flavonoids from S. stoloniferum were optimized by Box-Behnken design-response surface methodology based on single factor test. Validation test was conducted. RESULTS: The optimal purification technology was sample solution pH 4.8, flow rate of eluent 2.0 BV/h, concentration of eluent 72%. The purification rate of total flavonoids in 3 batches of samples was 72.34% (RSD=1.77%, n=3) in validation test, relative errors of which to predicted value (73.99%) was 2.13%. CONCLUSIONS: The optimal purification technology is stable and feasible, and can be used for the purification of total flavonoids from S. stoloniferum.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: China Pharmacy Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: China Pharmacy Año: 2019 Tipo del documento: Artículo