Meta-analysis of the Efficacy and Safety of Ⅹa Factor Inhibitors in the Prevention and Treatment of Venous Thromboembolism in Cancer Patients / 中国药房
China Pharmacy
;
(12): 729-733, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-817554
ABSTRACT
OBJECTIVE:To systematicall y evaluate the efficacy and safety of a new oral anticoagulant Ⅹ a inhibitor (apixaban,rivaroxaban,edoxaban)in the prevention and treatment of venous thromboembolism (VTE)in cancer patients ,and to provide evidence-based reference for rational use of drugs in clinic. METHODS :Retrieved from Cochrane Library ,PubMed, Embase,CBM,CNKI,VIP and Wanfang database ,randomized controlled trials (RCTs)about Ⅹa inhibitor (trial group )versus routine treatment or placebo (control group )in the prevention and treatment of VTE in cancer patients were collected. After literature screening ,data extraction and quality evaluation was evaluated by using biasrisk evaluation tool recommended by Cochrane System Evaluator M anual 5.1.0,and Meta-analysis was conducted by using Rev Man 5.3 software. RESULTS :A total of 7 RCTs were included ,including 5 666 patients. Meta-analysis showed that recurrent rate of VTE in trial group was significantly lower than control group [RR =0.58,95%CI(0.47,0.71),P<0.000 01];there was no statistical significance in the incidence of major bleeding [RR =1.12,95%CI(0.67,1.85),P=0.67] and clinically relevant non-major bleeding [RR =1.06,95%CI(0.72,1.55), P=0.77] between 2 groups. CONCLUSIONS :Ⅹa inhibitors can effectively reduce the recurrent risk of VTE in cancer patients , safety comparable with routine treatment (placebo).
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Ensayo Clínico Controlado
/
Revisiones Sistemáticas Evaluadas
Idioma:
Chino
Revista:
China Pharmacy
Año:
2020
Tipo del documento:
Artículo
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