Research progresses and the effection of traditional Chinese medicine of pyroptosis and Alzheimer disease / 医学研究生学报

ABSTRACT

Pyroptosis is a new type of programmed cell death .Pyroptosis tightly controls inflammatory response and destroys cell membranes, which finally induces cell death. From the current knowledge of the role of pyroptosis in Alzheimer disease, we can see that there are several connections between pyroptosis and Alzheimer disease. Frist of all, Inflammasome might play a major role in triggering Amyloid plaques-clumps of protein accumulation. Second, pyroptosis might activate caspase-1 for the subsequent maturation of pro-inflammatory cytokines,IL-1β and IL-18, which could be implicated in the execution of inflammatory response. Third, pyroptosis leads to neuronal cell death which is associated with pathogenetic mechanisms in Alzheimer disease. The goal of this article is to discuss the connection between Pyroptosis and Alzheimer disease so to find out the new therapeutic strategies targeting Alzheimer Disease.