Advances in studies on cancerous pain-related ion channels / 医学研究生学报

ABSTRACT

With the improvement of tumor diagnosis and treatment, the survival time in cancer patients has been gradually prolonged, but the complications such as severe pain are often found. Due to the unrevealed mechanisms of cancer pain, clinical analgesic treatments are unsatisfied needs , and the cancerous pain seriously affected the life quality of icancer patients. Ion channels are the transmembrane glycoproteins which produce and transmit electrical signals when activated, and involved in the regulation of a variety of physiological and pathological processes. Alterations in the ion channel function may play an important role in the formation and maintenance of cancer pain. In this review, the research developments of several major ion channels in the mechanisms of cancer pain in recent years are summarized, which can provide some useful references for the study of ion channel and related drug development of cancer pain.