The target sites and structural characteristic of bispecific antibodies in cancer therapy / 医学研究生学报

ABSTRACT

Bispecific antibodies, that are the second generation of new type of antibodies with two specific antigens or epitopes binding sites, can combine with target cells and effector cells (or molecules) at the same time. The recent studies demonstrated that Bispecific antibodies possess the immense therapeutic potential for cancer, ASID and autoimmune diseases. In this review, the various targets and function, the underlying mechanisms, and the application progress of Bispecific antibodies in cancer therapy were discussed.