The role and research progress of PLOD2 in tumor metastasis / 医学研究生学报

ABSTRACT

Tumor invasion and metastasis are the main factors leading to poor prognosis of cancer patients.In recent years, studies have found that collagen fiber remodeling in extracellular matrix(ECM) can promote tumor invasion and metastasis . Lysine hydroxylase 2(PLOD2) is the only lysine hydroxylase that changes the pattern of collagen fiber cross-linking and remodeling. It is highly expressed in many tumors and is closely related to tumor invasion and metastasis,Therefore, in-depth study of the role and mechanism of PLOD2 in tumor metastasis is of great scientific value for judging tumor prognosis and preventing tumor invasion and metastasis.This article reviews the recent advances in the role and potential mechanisms of PLOD2 in tumor invasion and metastasis.